Autoradiography

The Offspring team has many years of experience with autoradiography techniques, supporting research units within the pharmaceutical and biotechnology industry

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Offspring Biosciences can offer support in:

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- Profiling of drug binding properties on tissue sections from human or animal organs. This includes development of ligands for PET imaging, supporting clinical diagnostics and efficacy of drug treatments

- Demonstrate target engagement analyses of receptor occupancy and functional activation of receptors in vitro analyses of compound distribution after in vivo exposure

- Comparative analyses of the distribution of bound compound within the tissues combined with other measurements, such as: the distribution of the corresponding drug-binding protein, or markers for cell phenotype, or pathology, on consecutive or individual tissue sections