Anne Morinville, Bengt Fundin, Luc Meury, Anders Juréus, Kristian Sandberg, Johannes Krupp, Sultan Ahmad, Dajan O'Donnell
J Comp Neurol. 2007 Oct 20;504(6):680-9
DOI: https://doi.org/10.1002/cne.21484
Abstract
It is generally accepted that the voltage-gated, tetrodotoxin-sensitive sodium channel, NaV1.7, is selectively expressed in peripheral ganglia. However, global deletion in mice of NaV1.7 leads to death shortly after birth (Nassar et al. [2004] Proc. Natl. Acad. Sci. U. S. A. 101:12706–12711), suggesting that this ion channel might be more widely expressed. To understand better the potential physiological function of this ion channel, we examined NaV1.7 expression in the rat by in situ hybridization and immunohistochemistry. As expected, highest mRNA expression levels are found in peripheral ganglia, and the protein is expressed within these ganglion cells and on the projections of these neurons in the central nervous system. Importantly, we found that NaV1.7 is present in discrete rat brain regions, and the unique distribution pattern implies a central involvement in endocrine and autonomic systems as well as analgesia. In addition, NaV1.7 expression was detected in the pituitary and adrenal glands. These results indicate that NaV1.7 is not only involved in the processing of sensory information but also participates in the regulation of autonomic and endocrine systems; more specifically, it could be implicated in such vital functions as fluid homeostasis and cardiovascular control.
The intricate distribution patterns of the voltage-gated sodium channel Na(v)1.7 in rats offer profound insights into its role within the autonomic and endocrine systems. Expression levels in these systems indicate its potential significance in various physiological processes. Through careful examination, researchers can uncover the nuanced functions governed by this channel. You can Find this channel predominantly in regions associated with autonomic regulation, suggesting its involvement in modulating bodily functions such as heart rate and blood pressure. Beyond its role in the autonomic system, you could try these out for its presence in the endocrine system, where it may influence hormone secretion and regulation. Understanding its distribution sheds light on the intricate network of molecular interactions governing physiological responses.