Biosciences
Offspring
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While you Wait, Explore the Science
Want to get a better sense of how we approach translational research? Take a look at some of our latest white papers, technical articles, and scientific insights.
From human tissue validation to spatial biology and target engagement, explore some of the questions that matter most in translational drug development.
Case Study in Accelerating Exidavnemab to Phase 2:
A Blueprint for Human Tissue Based Target Validation.
Breakthroughs in CNS disease and compounds navigation the blood brain barrier remain one of the trickiest translational gaps to bridge.
The era of relying on the inbred mouse to predict human response is at an end. The era of Tissue-First Drug Development has arrived.
See how human tissue based evidence can help de risk antibody development before a Phase II trial fails to evolve to Phase III.
Models are extraordinarily useful.
They are also approximations.
Explore the biomolecular reasons why promising preclinical results can fail in humans (species specific biology, incomplete disease representation, hidden off-target effects) and what we can learn from histories greatest translational gaps.