Insights & Updates

For over a decade, the pharmaceutical industry has universally admired the structured translational frameworks pioneered by industry leaders. When AstraZeneca instituted the "5R Framework" (Right Target, Right Tissue, Right Safety, Right Patient, Right Commercial) and Pfizer deployed their "Three Pillars of Survival" (now the SOCA paradigm), the results were undeniable. AstraZeneca drove their Phase III success rate from a dismal 4% to 19% (1), while Pfizer saw a tenfold impr

Neurology is one of the most complex and challenging frontiers in medicine, encompassing a vast spectrum of disorders that affect the central and peripheral nervous system, behavioral and mood changes, and extending changes in hormones and the microbiome. This includes progressive neurodegenerative conditions like Alzheimer’s Disease and Parkinson’s Disease, defined by the toxic aggregation of proteins like Amyloid-beta and alpha-synuclein; autoimmune disorders like Multiple

The transition from preclinical promise to clinical efficacy, the so-called "Translational Gap", remains the most perilous stage of drug development. Nowhere is this chasm wider than in neurodegeneration, where billions of dollars and years of research are lost when promising candidates fail in late-stage trials. The fundamental reason is often a stark divergence between the simplified environments of preclinical models and the complex, heterogeneous reality of human disease.

Human Tissue Analysis in CNS drug development helps to bridge the translational gap and de-risk clinical development. New research on Alzheimers Disease, Palsy, Parkinsons, Multi System Atrophy and more offer insights into treatment development.

Offspring Biosciences is pleased to announce our expanded technical capacity with the purchase and installment of a Roche/Ventana Discovery Ultra tissue staining platform which significantly enhances our ability to deliver highly reliable, informative and 7-Plex Multiplex IHC & ISH Services | Preclinical CRO | Offspring Bioefficient support to our customers The Discovery Ultra platform allows for parallel and fully individualized processing of up to 30 slide-mounted tissue

In a recently published study in Plos One, a research team led by Dr Sara Hansson at AstraZeneca presented data which demonstrate that secretagogin, an intracellular calcium-binding intracellular protein highly enriched in pancreatic islets, may serve as biomarker in the blood for beta cell dysfunction in individuals with type 2 diabetes Offspring supported this project by performing multiplexed immunofluorescence-based detection of secretagogin selectively within the insulin