Anne Morinville, Bengt Fundin, Luc Meury, Anders Juréus, Kristian Sandberg, Johannes Krupp, Sultan Ahmad, Dajan O'Donnell
J Comp Neurol. 2007 Oct 20;504(6):680-9
DOI: https://doi.org/10.1002/cne.21484
Abstract
It is generally accepted that the voltage-gated, tetrodotoxin-sensitive sodium channel, NaV1.7, is selectively expressed in peripheral ganglia. However, global deletion in mice of NaV1.7 leads to death shortly after birth (Nassar et al. [2004] Proc. Natl. Acad. Sci. U. S. A. 101:12706–12711), suggesting that this ion channel might be more widely expressed. To understand better the potential physiological function of this ion channel, we examined NaV1.7 expression in the rat by in situ hybridization and immunohistochemistry. As expected, highest mRNA expression levels are found in peripheral ganglia, and the protein is expressed within these ganglion cells and on the projections of these neurons in the central nervous system. Importantly, we found that NaV1.7 is present in discrete rat brain regions, and the unique distribution pattern implies a central involvement in endocrine and autonomic systems as well as analgesia. In addition, NaV1.7 expression was detected in the pituitary and adrenal glands. These results indicate that NaV1.7 is not only involved in the processing of sensory information but also participates in the regulation of autonomic and endocrine systems; more specifically, it could be implicated in such vital functions as fluid homeostasis and cardiovascular control.
Understanding the distribution of the voltage-gated sodium channel Na is pivotal in comprehending neuronal excitability and signaling. If you're interested in delving deeper into this topic, why not try this out experimental techniques such as immunohistochemistry and electron microscopy? They offer valuable tools for visualizing the spatial organization of Na channels within neurons. You can Find Out More about the implications of Na channel distribution on neuronal function and dysfunction. These channels play a fundamental role in action potential generation and propagation. By investigating their localization within neuronal membranes, researchers can gain insights into various physiological and pathological processes, including neurological disorders. Furthermore, deciphering the intricate mechanisms governing Na channel distribution could unveil potential therapeutic targets for such conditions.